10 articles in Research Reviews.
Three randomized trials put an eating window head to head with ordinary calorie restriction. The weight came off about the same either way. Here's what that means if you're on a GLP-1.
PJ's latest reel asks the question out loud, so here's the honest answer. What the randomized trials actually show about GLP-1-type medications and obstructive sleep apnea, what's FDA-approved today, and what's still emerging.
It is the question almost everyone on a GLP-1 quietly searches at 2am: can I ever stop? Two randomized withdrawal trials, SURMOUNT-4 and STEP 1, have a clear and uncomfortable answer about what happens to the weight when the medication goes away.
For years, "food noise" was a word patients used and no test could see. At EASD 2026, a brain-imaging study of an investigational GLP-1 drug showed food-cue responses changing in the scanner — matching what people have reported all along.
In one semaglutide trial, 12% of people still hadn't lost 5% four weeks after reaching the full dose. Most of them got there anyway — here's the data.
A Gila monster survives on a handful of meals a year. To manage it, it evolved a version of a human gut hormone that lasts hours instead of minutes — and that molecule became the first GLP-1 medication.
For years, people on GLP-1 medications reported wanting alcohol less — without trying to. Researchers have now tested it properly, and the finding is narrower and more interesting than the headlines suggest.
The hormone behind semaglutide was found in 1987 and was almost useless as a medicine — it disappeared from the blood in about two minutes. The fix came from a lizard in the Arizona desert.
Fatigue is the second most-reported GLP-1 side effect, and feeling cold barely appears in the official documentation at all. Here's what's usually behind both — and the handful of things worth actually checking.
GLP-1 drugs like semaglutide drive real weight loss — but some of it is lean muscle. Here's what the evidence says, and how to protect muscle while you lose fat.